Try checking the 'Comments' page of the mod to see what others have to say. Causes fallout 3 crashes: teamspeak 'overwolf', ASUS xonar 'gx' & GamerOSD. Dual monitors Either disable 2nd monitor (Windows key + P) or set same res on both. It will validate your game, detect your graphics card and create a fallout.ini. If the mod is 'modifying/patching' another mod, then it really should have instructions. Start Fallout, click Play, push the escape key and Quit.
If the mod is 'replacing' things (especially 'meshes' and 'textures', aka 'art assets'), be certain to 'toggle ArchiveInvalidation' off-and-back-on again every time you add or remove such files. In which case, see the ' Issue - Fix a missing or solid color texture problem' entry under the ' Solutions to Mesh -Red Kite- icon or Texture -solid or off color- problems' section of the wiki ' Fallout NV Mod Conflict Troubleshooting' article. If you install it but don't see what you expect, then the mod was probably packaged in a 'non-standard' fashion. Note this mod is not compatible with others that change NPCs, so make sure to deactivate this to avoid messing up your game if you install some others. Most of the time a mod manager will be able to work that out from the archive package structure, but not always. Speaking in VERY general terms, if a mod is adding 'something new', then it is supposed to be 'self-contained' and all you need to do is place it's files where they belong.